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- B8abbe0f60e6a7c6af9c4ff0fb19c1bad hasDbXref "PMID:25968320" @default.
- B8abbe0f60e6a7c6af9c4ff0fb19c1bad type Axiom @default.
- B8abbe0f60e6a7c6af9c4ff0fb19c1bad annotatedProperty IAO_0000115 @default.
- B8abbe0f60e6a7c6af9c4ff0fb19c1bad annotatedSource EMAPA_18999 @default.
- B8abbe0f60e6a7c6af9c4ff0fb19c1bad annotatedTarget "The sinovaginal bulb (svb) (syn: sinus vagina, vaginal bulb, lower vagina) (TS:24-TS:27) is comprised of epithelium, lamina propria, muscle, adventita and developing vasculature. A solid epithelial cord derived from the urogenital sinus ridge, located adjacent to the dorsal epithelium of the pelvic urethra and connects the epithelium of the pelvic urethra to the epithelium of the paramesonephric duct-derived upper vagina. Part of pelvic urethra of female and part of vagina. In males, androgens stop the caudal growth of the nephric ducts. In females, the remaining cells of the nephric duct and the paramesonephric duct-derived upper vagina continue to migrate down the pelvic urethra and have fused to the sinovaginal bulb by E18 (TS:26). In newborn mice, the nonpatent, vagina is comprised of the sinovaginal bulb and PND-derived vaginal epithelium fused together. By P3, the proportion of PND-derived vaginal epithelium is larger than the proportion made up by the sinovaginal bulb and the downward migration of the upper vagina continues along the pelvic urethra. Throughout this time, the sinovaginal bulb is a solid, flat epithelial cord. The vagina reaches the perineum by P8 and opens during puberty (~P28). The entire vaginal epithelium of adult is derived from Hoxb7-Cre expressing PND and does not contain epithelia derived from the sinovaginal bulb or nephric duct epithelium. Vulvar epithelium does contain cells derived from urogenital sinus. The solid cord of the vagina canalises at the time of vaginal opening and the sinovaginal bulb becomes part of the vulvar epithelium." @default.