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- B8ac53aa87f9c0dbea6982f69e219956c NCIT_P378 "NCI" @default.
- B8ac53aa87f9c0dbea6982f69e219956c type Axiom @default.
- B8ac53aa87f9c0dbea6982f69e219956c annotatedProperty IAO_0000115 @default.
- B8ac53aa87f9c0dbea6982f69e219956c annotatedSource NCIT_C103298 @default.
- B8ac53aa87f9c0dbea6982f69e219956c annotatedTarget "A synthetic, small molecule inhibitor of the BET (Bromodomain and Extra-Terminal) family of bromodomain-containing proteins 2, 3 and 4 with potential antineoplastic activity. Upon administration, birabresib binds to the acetylated lysine recognition motifs on the bromodomain of BET proteins, thereby preventing the interaction between the BET proteins and acetylated histone peptides. This disrupts chromatin remodeling and gene expression. Prevention of the expression of certain growth-promoting genes, including c-Myc-dependent target genes, may lead to an inhibition of tumor cell growth. Characterized by a tandem repeat of bromodomain at the N-terminus, the BET proteins BRD2, BRD3, BRD4 are transcriptional regulators that play an important role in cellular growth." @default.