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- B8ba0a73772a76b7a56fa6279f70e00ef NCIT_P378 "NCI" @default.
- B8ba0a73772a76b7a56fa6279f70e00ef type Axiom @default.
- B8ba0a73772a76b7a56fa6279f70e00ef annotatedProperty IAO_0000115 @default.
- B8ba0a73772a76b7a56fa6279f70e00ef annotatedSource NCIT_C1102 @default.
- B8ba0a73772a76b7a56fa6279f70e00ef annotatedTarget "The phosphate salt of a fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic activity. Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite may inhibit DNA polymerase alpha, ribonucleotide reductase and DNA primase, thereby interrupting DNA synthesis and inhibiting tumor cell growth." @default.