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- B8be75da23401babc1018c66a30a1f6ee NCIT_P378 "NCI" @default.
- B8be75da23401babc1018c66a30a1f6ee type Axiom @default.
- B8be75da23401babc1018c66a30a1f6ee annotatedProperty IAO_0000115 @default.
- B8be75da23401babc1018c66a30a1f6ee annotatedSource NCIT_C103863 @default.
- B8be75da23401babc1018c66a30a1f6ee annotatedTarget "A bispecific monoclonal antibody directed against the human epidermal growth factor receptor ErbB3 (Her3) and the human insulin-like growth factor-1 receptor (IGF-1R), with potential antineoplastic activity. The anti-IGF-1R targeting arm of Istiratumab binds to IGF-1R on tumor cells thereby preventing the binding of the natural ligands IGF-1, 2 and heregulin (HRG) to IGF-1R; the anti-ErbB3 therapeutic arm prevents the binding of neuregulin (NRG) to ErbB3. This prevents the activation of the PI3K/AKT signal transduction pathway and may result in both the induction of apoptosis and a decrease in cellular proliferation in IGF-1R and ErbB3-overexpressing tumor cells. IGF-1R, a receptor tyrosine kinase of the insulin receptor superfamily, and ErB3, a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases, are frequently overexpressed in solid tumors." @default.