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- B8c3a511ea837a89456e71917839f7912 NCIT_P378 "NCI" @default.
- B8c3a511ea837a89456e71917839f7912 type Axiom @default.
- B8c3a511ea837a89456e71917839f7912 annotatedProperty IAO_0000115 @default.
- B8c3a511ea837a89456e71917839f7912 annotatedSource NCIT_C152811 @default.
- B8c3a511ea837a89456e71917839f7912 annotatedTarget "An orally bioavailable, hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor (HIF-PHI), with potential anti-anemic and anti-inflammatory activities. Upon administration, vadadustat binds to and inhibits HIF-PH, an enzyme responsible for the degradation of transcription factors in the HIF family under normal oxygen conditions. This prevents HIF breakdown and promotes HIF activity. Increased HIF activity leads to an increase in endogenous erythropoietin production, thereby enhancing erythropoiesis. It also reduces the expression of the peptide hormone hepcidin, improves iron availability, and boosts hemoglobin (Hb) levels. HIF regulates the expression of genes in response to reduced oxygen levels, including genes required for erythropoiesis and iron metabolism. In addition, HIF 1-alpha (HIF1A) may play a role in reducing inflammation during acute lung injury (ALI) through HIF-dependent control of glucose metabolism in the alveolar epithelium." @default.