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- B8c82a259ab34439b21b57e0c59f4b082 NCIT_P378 "NCI" @default.
- B8c82a259ab34439b21b57e0c59f4b082 type Axiom @default.
- B8c82a259ab34439b21b57e0c59f4b082 annotatedProperty IAO_0000115 @default.
- B8c82a259ab34439b21b57e0c59f4b082 annotatedSource NCIT_C102784 @default.
- B8c82a259ab34439b21b57e0c59f4b082 annotatedTarget "A humanized IgG1 monoclonal antibody against CD123 (Interleukin-3 receptor alpha chain or IL3RA) with potential antineoplastic activity. Upon intravenous administration, talacotuzumab binds to and neutralizes CD123. This may inhibit IL-3-dependent signaling and may inhibit proliferation and differentiation in CD123-positive tumor cells. CSL362 contains an engineered Fc region which increases its binding affinity to Fc-gamma receptors on the surface of natural killer (NK) cells thereby initiating antibody-dependent cellular cytotoxicity (ADCC). CD123 is normally expressed on committed blood progenitor cells in the bone marrow; its overexpression is associated with increased leukemic cell proliferation and aggressiveness." @default.