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- B8caee1c91c158630c83f5c692765eb9a NCIT_P378 "NCI" @default.
- B8caee1c91c158630c83f5c692765eb9a type Axiom @default.
- B8caee1c91c158630c83f5c692765eb9a annotatedProperty IAO_0000115 @default.
- B8caee1c91c158630c83f5c692765eb9a annotatedSource NCIT_C40818 @default.
- B8caee1c91c158630c83f5c692765eb9a annotatedTarget "Multidrug Resistance Inhibition involves interference with, or restraint of, the activities of biologic molecules or complexes involved in processes that increase the ability of cancer cells to counteract, defeat, or withstand the effects of multiple chemotherapeutic agents. Mechanisms involve decreased expression of multidrug efflux pumps (p-glycoprotein), altered glutathione metabolism, increased topoisomerase II activity, and changes in various cellular proteins. Inhibition results in increased transport of drug into, or decreased transport out of, cells and increased effectiveness of chemotherapeutic agents." @default.