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- B8ce938fda4d3e37766a8ee164ae90982 NCIT_P378 "NCI" @default.
- B8ce938fda4d3e37766a8ee164ae90982 type Axiom @default.
- B8ce938fda4d3e37766a8ee164ae90982 annotatedProperty IAO_0000115 @default.
- B8ce938fda4d3e37766a8ee164ae90982 annotatedSource NCIT_C78676 @default.
- B8ce938fda4d3e37766a8ee164ae90982 annotatedTarget "The sodium salt of atorvastatin, a synthetic lipid-lowering agent. Atorvastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent increases the number of LDL receptors on hepatic cell surfaces, enhancing the uptake and catabolism of LDL and reducing LDL production and the number of LDL particles, and lowers plasma cholesterol and lipoprotein levels. Like other statins, atorvastatin may also display direct antineoplastic activity, possibly by inhibiting farnesylation and geranylgeranylation of proteins such as small GTP-binding proteins, which may result in the arrest of cells in the G1 phase of the cell cycle. This agent may also sensitize tumor cells to cyctostatic drugs, possibly through the mTOR-dependent inhibition of Akt phosphorylation." @default.