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- B8d7053c657c8119d22f459a23f8e1fb1 NCIT_P378 "NCI" @default.
- B8d7053c657c8119d22f459a23f8e1fb1 type Axiom @default.
- B8d7053c657c8119d22f459a23f8e1fb1 annotatedProperty IAO_0000115 @default.
- B8d7053c657c8119d22f459a23f8e1fb1 annotatedSource NCIT_C20692 @default.
- B8d7053c657c8119d22f459a23f8e1fb1 annotatedTarget "Nuclear receptor coactivator genes encode a class of proteins that are recruited and serve as bridging molecules between the transcription initiation complex and nuclear receptors (NRs). Most of these coactivators interact with the AF-2 domain of NRs through one or several LXXLL motifs called NR box. Members of NRs includes the 5 steroid receptors and class II nuclear receptors. After binding to enhancer elements, transcription factors require transcriptional coactivator proteins to mediate their stimulation of transcription initiation. (NCI)" @default.