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- B8da40662633b20187d0cd0e0e35a55df NCIT_P378 "NCI" @default.
- B8da40662633b20187d0cd0e0e35a55df type Axiom @default.
- B8da40662633b20187d0cd0e0e35a55df annotatedProperty IAO_0000115 @default.
- B8da40662633b20187d0cd0e0e35a55df annotatedSource NCIT_C48000 @default.
- B8da40662633b20187d0cd0e0e35a55df annotatedTarget "The hydrochloride salt form of lidocaine, an aminoethylamide and a prototypical member of the amide class anesthetics. Lidocaine interacts with voltage-gated Na+ channels in the nerve cell membrane and blocks the transient increase in permeability of excitable membranes to Na+. This prevents the generation and conduction of nerve impulses and produces a reversible loss of sensation. Lidocaine hydrochloride also exhibits class IB antiarrhythmic effects. The agent decreases the flow of sodium ions into myocardial tissue, especially on the Purkinje network, during phase 0 of the action potential, thereby decreasing depolarization, automaticity and excitability." @default.