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- B8de4197b44fbbafdf725ea2147748bdf NCIT_P378 "NCI" @default.
- B8de4197b44fbbafdf725ea2147748bdf type Axiom @default.
- B8de4197b44fbbafdf725ea2147748bdf annotatedProperty IAO_0000115 @default.
- B8de4197b44fbbafdf725ea2147748bdf annotatedSource NCIT_C62049 @default.
- B8de4197b44fbbafdf725ea2147748bdf annotatedTarget "A short-acting benzodiazepine derivative with an imidazole structure and with anxiolytic, amnestic, hypnotic, anticonvulsant and sedative properties. Midazolam exerts its effect by binding to the benzodiazepine receptor at the gamma-aminobutyric acid (GABA) receptor-chloride ionophore complex in the central nervous system (CNS). This leads to an increase in the opening of chloride channels, membrane hyperpolarization and increases the inhibitory effect of GABA in the CNS. Midazolam may also interfere with the reuptake of GABA, thereby causing accumulation of GABA in the synaptic cleft." @default.