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- B8e816e01d5d206982c27d4b8f7d2095b NCIT_P378 "NCI" @default.
- B8e816e01d5d206982c27d4b8f7d2095b type Axiom @default.
- B8e816e01d5d206982c27d4b8f7d2095b annotatedProperty IAO_0000115 @default.
- B8e816e01d5d206982c27d4b8f7d2095b annotatedSource NCIT_C1541 @default.
- B8e816e01d5d206982c27d4b8f7d2095b annotatedTarget "A 24-base phosphorothiolate antisense oligodeoxynucleotide (ODN) for the proto-oncogene c-myb with potential antineoplastic activity. C-myb antisense oligonucleotide G4460 binds to codon sequences 2 to 9 of c-myb mRNA, inhibiting translation of the transcript. Suppression of c-myb expression with this agent may result in the restoration of normal differentiation pathways, increased antiproliferative effects, and the induction of apoptosis in early progenitor hematopoietic cells and in tumor cells that overexpress c-myb. Tumor-cell overexpression of c-myb blocks differentiation, promotes proliferation, and inhibits apoptosis." @default.