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- B8e83013b7276f7ad4f99c4504ca12d59 NCIT_P378 "NCI" @default.
- B8e83013b7276f7ad4f99c4504ca12d59 type Axiom @default.
- B8e83013b7276f7ad4f99c4504ca12d59 annotatedProperty IAO_0000115 @default.
- B8e83013b7276f7ad4f99c4504ca12d59 annotatedSource NCIT_C900 @default.
- B8e83013b7276f7ad4f99c4504ca12d59 annotatedTarget "A naturally-occurring acid of retinol. Tretinoin binds to and activates retinoic acid receptors (RARs), thereby inducing changes in gene expression that lead to cell differentiation, decreased cell proliferation, and inhibition of tumorigenesis. This agent also inhibits telomerase, resulting in telomere shortening and eventual apoptosis of some tumor cell types. The oral form of tretinoin has teratogenic and embryotoxic properties." @default.