Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/B8e9897b4ea88c8b3bc3f9f17fc008c35> ?p ?o ?g. }
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- B8e9897b4ea88c8b3bc3f9f17fc008c35 NCIT_P378 "NCI" @default.
- B8e9897b4ea88c8b3bc3f9f17fc008c35 type Axiom @default.
- B8e9897b4ea88c8b3bc3f9f17fc008c35 annotatedProperty IAO_0000115 @default.
- B8e9897b4ea88c8b3bc3f9f17fc008c35 annotatedSource NCIT_C113437 @default.
- B8e9897b4ea88c8b3bc3f9f17fc008c35 annotatedTarget "A synthetic, 5-amino acid peptide and Innate Defense Regulator (IDR), with immunomodulating, anti-inflammatory, anti-infective and anti-mucositis activities. Upon intravenous administration, dusquetide binds to the ZZ domain of sequestosome-1, also called p62, and activates regulatory signaling transduction pathways involved in the modulation of the innate immune system, such as those mediated by mitogen-activated protein kinase (MAPK) p38 and CCAAT-enhancer-binding protein. This agent promotes monocyte and macrophage recruitment to, and accelerates healing in damaged and infected tissue; it suppresses inflammation through the regulation of the expression of multiple cytokines. This agent may prevent or decrease chemo- or radiotherapy-induced mucositis as well as other types of infection. p62, an intracellular adaptor protein that functions downstream of certain signaling receptors, plays a key role in the activation of the innate immune system." @default.