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- B8ec3f23e1875b91a3377dd6dc3d41188 NCIT_P378 "NCI" @default.
- B8ec3f23e1875b91a3377dd6dc3d41188 type Axiom @default.
- B8ec3f23e1875b91a3377dd6dc3d41188 annotatedProperty IAO_0000115 @default.
- B8ec3f23e1875b91a3377dd6dc3d41188 annotatedSource NCIT_C61748 @default.
- B8ec3f23e1875b91a3377dd6dc3d41188 annotatedTarget "An oral prostacyclin and a metabolite of arachidonic acid with antihypertensive and platelet inhibitory properties. Epoprostenol binds to prostacyclin receptors on platelet surfaces, subsequently activating platelet membrane adenyl cyclase and resulting in increased cAMP levels. The elevated cAMP triggers signal transduction that leads to vasodilations. In addition, this agent also functions as an antagonist of thromboxane A2, thereby resulting in direct vasodilation of pulmonary and systemic arterial vascular beds, and inhibition of platelet aggregation." @default.