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- B8eea24f16700c4329145d6e9df2f707c NCIT_P378 "NCI" @default.
- B8eea24f16700c4329145d6e9df2f707c type Axiom @default.
- B8eea24f16700c4329145d6e9df2f707c annotatedProperty IAO_0000115 @default.
- B8eea24f16700c4329145d6e9df2f707c annotatedSource NCIT_C17275 @default.
- B8eea24f16700c4329145d6e9df2f707c annotatedTarget "Ubiquitous heterodimeric human Calcineurin is Ca(2+)/calmodulin-regulated protein phosphatase involved in many biologic activities as a modifier of phosphorylation status. Composed of widely expressed or tissue-restricted 55-60-kDa calmodulin-binding catalytic subunit (PPP Phosphatase/PP-2B Family) and conserved 19-kD Ca(2+)-sensitive regulatory subunit, Calcineurin appears to regulate glycolytic metabolism, nuclear translocation of NFATC1 transcription factor, sperm motility, and dopaminergic signal transduction and NMDA receptor-dependent synaptic plasticity. (NCI)" @default.