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- B8eeee1ad6261054fdc32af40358f5c05 NCIT_P378 "NCI" @default.
- B8eeee1ad6261054fdc32af40358f5c05 type Axiom @default.
- B8eeee1ad6261054fdc32af40358f5c05 annotatedProperty IAO_0000115 @default.
- B8eeee1ad6261054fdc32af40358f5c05 annotatedSource NCIT_C95123 @default.
- B8eeee1ad6261054fdc32af40358f5c05 annotatedTarget "An orally available synthetic mimetic of the growth hormone (GH) secretagogue ghrelin with potential anti-cachexia activity. Upon oral administration, macimorelin mimics endogenous ghrelin by stimulating appetite and binds to the growth hormone secretagogue receptor GHSR in the central nervous system, thereby mimicking the GH-releasing effects of ghrelin from the pituitary gland. Stimulation of GH secretion increases insulin-like growth factor-I (IGF-I) levels which may further stimulate protein synthesis. In addition, ghrelin reduces the production of pro-inflammatory cytokines, which may play a direct role in cancer-related loss of appetite." @default.