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- B8fbac5ba28e9e3b8a015c8191e49370c NCIT_P378 "NCI" @default.
- B8fbac5ba28e9e3b8a015c8191e49370c type Axiom @default.
- B8fbac5ba28e9e3b8a015c8191e49370c annotatedProperty IAO_0000115 @default.
- B8fbac5ba28e9e3b8a015c8191e49370c annotatedSource NCIT_C62040 @default.
- B8fbac5ba28e9e3b8a015c8191e49370c annotatedTarget "A semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. Irinotecan, a prodrug, is converted to a biologically active metabolite 7-ethyl-10-hydroxy-camptothecin (SN-38) by a carboxylesterase-converting enzyme. One thousand-fold more potent than its parent compound irinotecan, SN-38 inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptotic cell death. Because ongoing DNA synthesis is necessary for irinotecan to exert its cytotoxic effects, it is classified as an S-phase-specific agent." @default.