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- B902cf99ac49c56f0e2a9eafb8ccc2167 NCIT_P378 "NCI" @default.
- B902cf99ac49c56f0e2a9eafb8ccc2167 type Axiom @default.
- B902cf99ac49c56f0e2a9eafb8ccc2167 annotatedProperty IAO_0000115 @default.
- B902cf99ac49c56f0e2a9eafb8ccc2167 annotatedSource NCIT_C71149 @default.
- B902cf99ac49c56f0e2a9eafb8ccc2167 annotatedTarget "An embolic material composed of microspheres of polyvinyl alcohol (PVA) polymers loaded with doxorubicin hydrochloride with antineoplastic activity. Doxorubicin hydrochloride-loaded microspheres may be used as a drug delivery vehicle during embolization of tumor vasculature. Doxorubicin intercalates DNA, interferes with catalytic activity of topoisomerase II, and causes DNA adducts and other DNA damage, resulting in tumor cell growth inhibition and apoptosis. When used in tumor vasculature embolization, this preparation may provide more tumor-specific treatment with doxorubicin compared to the systemic administration of doxorubicin, thereby reducing the systemic toxicity of doxorubicin." @default.