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- B908081cbb79332bb8e69716fdfc0a5db NCIT_P378 "NCI" @default.
- B908081cbb79332bb8e69716fdfc0a5db type Axiom @default.
- B908081cbb79332bb8e69716fdfc0a5db annotatedProperty IAO_0000115 @default.
- B908081cbb79332bb8e69716fdfc0a5db annotatedSource NCIT_C1723 @default.
- B908081cbb79332bb8e69716fdfc0a5db annotatedTarget "A recombinant, chimeric monoclonal antibody directed against the epidermal growth factor (EGFR) with antineoplastic activity. Cetuximab binds to the extracellular domain of the EGFR, thereby preventing the activation and subsequent dimerization of the receptor; the decrease in receptor activation and dimerization may result in an inhibition in signal transduction and anti-proliferative effects. This agent may inhibit EGFR-dependent primary tumor growth and metastasis. EGFR is overexpressed on the cell surfaces of various solid tumors." @default.