Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/B90dd5d66f8fe1a1fb7718b6515bf8b5f> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- B90dd5d66f8fe1a1fb7718b6515bf8b5f NCIT_P378 "NCI" @default.
- B90dd5d66f8fe1a1fb7718b6515bf8b5f type Axiom @default.
- B90dd5d66f8fe1a1fb7718b6515bf8b5f annotatedProperty IAO_0000115 @default.
- B90dd5d66f8fe1a1fb7718b6515bf8b5f annotatedSource NCIT_C111566 @default.
- B90dd5d66f8fe1a1fb7718b6515bf8b5f annotatedTarget "A radioconjugate comprised of the orally available reversible 20S proteasome inhibitor ixazomib and labeled with the isotope carbon C 14. Upon administration, the ixazomib moiety hydrolyzes and generates its active form, MLN2238, which inhibits the activity of the 20S catalytic core subunit of the proteasome. This blocks the targeted proteolysis normally performed by the proteasome, which results in an accumulation of unwanted or misfolded proteins. The accumulation of protein may disrupt various cell signaling pathways, induce apoptosis, and inhibit tumor growth. In addition, this agent targets tumor suppressor microRNA-33b (miR-33b). Labeling with the radioactive tracer carbon C 14 allows for evaluation of ixazomib's absorption, distribution, metabolism and excretion (ADME)." @default.