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- B91018a8c1acfb027bd7b38fef79c4261 NCIT_P378 "NCI" @default.
- B91018a8c1acfb027bd7b38fef79c4261 type Axiom @default.
- B91018a8c1acfb027bd7b38fef79c4261 annotatedProperty IAO_0000115 @default.
- B91018a8c1acfb027bd7b38fef79c4261 annotatedSource NCIT_C102568 @default.
- B91018a8c1acfb027bd7b38fef79c4261 annotatedTarget "A lipid microsphere (LM)-based formulation containing the poorly water soluble taxane docetaxel, a semi-synthetic analogue of paclitaxel, with antineoplastic activity. Docetaxel binds specifically to the beta-tubulin subunit of the microtubule, stabilizing tubulin and inhibiting microtubule disassembly, which causes cell cycle arrest at the G2/M phase and leads to cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and induces various mediators of the inflammatory response. Compared to docetaxel alone, the LM formulation may enhance stability, improve efficacy and may reduce toxicity; this formulation does not contain toxic detergents needed to solubilize docetaxel which further improves its side effect profile." @default.