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- B91e6e91a324559fcf9e5fb3a98f41954 NCIT_P378 "NCI" @default.
- B91e6e91a324559fcf9e5fb3a98f41954 type Axiom @default.
- B91e6e91a324559fcf9e5fb3a98f41954 annotatedProperty IAO_0000115 @default.
- B91e6e91a324559fcf9e5fb3a98f41954 annotatedSource NCIT_C81934 @default.
- B91e6e91a324559fcf9e5fb3a98f41954 annotatedTarget "An orally bioavailable, small-molecule inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity. Upon oral administration, ibrutinib binds to and irreversibly inhibits BTK activity, thereby preventing both B-cell activation and B-cell-mediated signaling. This leads to an inhibition of the growth of malignant B cells that overexpress BTK. BTK, a member of the src-related BTK/Tec family of cytoplasmic tyrosine kinases, is required for B cell receptor signaling, plays a key role in B-cell maturation, and is overexpressed in a number of B-cell malignancies. The expression of BTK in tumor cells is also associated with increased proliferation and survival." @default.