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- B92235f8f4da94ccdfd8a5c146403097c NCIT_P378 "NCI" @default.
- B92235f8f4da94ccdfd8a5c146403097c type Axiom @default.
- B92235f8f4da94ccdfd8a5c146403097c annotatedProperty IAO_0000115 @default.
- B92235f8f4da94ccdfd8a5c146403097c annotatedSource NCIT_C29267 @default.
- B92235f8f4da94ccdfd8a5c146403097c annotatedTarget "The hydrochloride salt form of moexipril, a prodrug and non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Moexipril hydrochloride is hydrolized into its active form moexiprilat, which competitively inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the actions of the potent vasoconstrictor angiotensin II and leads to vasodilatation. It also prevents angiotensin II-induced aldosterone secretion by the adrenal cortex, thereby promoting diuresis and natriuresis. Moexipril hydrochloride also directly suppresses renin release." @default.