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- B9291ce898bf9b460b0d5421d4ba165e5 NCIT_P378 "NCI" @default.
- B9291ce898bf9b460b0d5421d4ba165e5 type Axiom @default.
- B9291ce898bf9b460b0d5421d4ba165e5 annotatedProperty IAO_0000115 @default.
- B9291ce898bf9b460b0d5421d4ba165e5 annotatedSource NCIT_C105813 @default.
- B9291ce898bf9b460b0d5421d4ba165e5 annotatedTarget "A human serotype 5, replication-defective, first generation adenoviral vector, with the viral E1a and E3 protein encoding regions deleted, which is engineered to express the soluble, immune-mediated stimulatory gene human fms-like tyrosine kinase 3 ligand (Flt3L), under the transcriptional control of the CMV promoter, with potential immunostimulating activity. Upon administration, Ad-hCMV-Flt3L is transduced into tumor cells and Flt3L is expressed. Flt3L stimulates both the proliferation of dendritic cells (DCs) and their migration to the tumor site. Upon exposure to the tumor-associated antigens (TAA) released from dying glioma cells, which were killed by thymidine kinase-mediated valacyclovir-induced tumor cell death, the DCs initiate a specific immune response against any remaining TAA-expressing tumor cells. Flt3L is a hematopoietic growth factor and ligand for the Flt3 tyrosine kinase receptor." @default.