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- B93553712565a8e891172c92e3d26f1cf NCIT_P378 "NCI" @default.
- B93553712565a8e891172c92e3d26f1cf type Axiom @default.
- B93553712565a8e891172c92e3d26f1cf annotatedProperty IAO_0000115 @default.
- B93553712565a8e891172c92e3d26f1cf annotatedSource NCIT_C649 @default.
- B93553712565a8e891172c92e3d26f1cf annotatedTarget "The hydrochloride salt of the substituted benzamide metoclopramide, a para-aminobenzoic acid (PABA) derivative that is structurally related to procainamide, with gastroprokinetic and antiemetic activities. Metoclopramide binds to dopamine 2 (D2) receptors in the peripheral nervous system (PNS), antagonizing dopamine-mediated relaxation of gastrointestinal smooth muscle and promoting gastroprokinesis; the pyloric sphincter and the duodenal bulb are relaxed, peristalsis of the duodenum and jejunum increase, and gastric emptying and intestinal transit accelerate. This agent may also increase the resting tone of the lower esophagus sphincter (LES), preventing acid reflux. In the central nervous system (CNS), metoclopramide antagonizes D2 dopamine receptors in the chemoreceptive trigger zone (CTZ) of the medulla, thereby preventing nausea and vomiting." @default.