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- B937b8a069177d1b3ee977c5e06e35eea NCIT_P378 "NCI" @default.
- B937b8a069177d1b3ee977c5e06e35eea type Axiom @default.
- B937b8a069177d1b3ee977c5e06e35eea annotatedProperty IAO_0000115 @default.
- B937b8a069177d1b3ee977c5e06e35eea annotatedSource NCIT_C71722 @default.
- B937b8a069177d1b3ee977c5e06e35eea annotatedTarget "A hypoxia-activated prodrug of the cytotoxin bromo-isophosphoramide mustard (Br-IPM) conjugated with 2-nitroimidazole, with potential antineoplastic activity. When exposed to hypoxic conditions, such as those found in hypoxic tumors, the 2-nitroimidazole moiety of evofosfamide is reduced. This releases the DNA-alkylating Br-IPM moiety, which introduces intra- and inter-strand DNA crosslinks in nearby cells; the crosslinks inhibit both DNA replication and cell division, and may lead to apoptosis of cells in the tumor. The inactive form of the prodrug is stable under normoxic conditions, which may limit systemic toxicity." @default.