Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/B939a0e6583fb28fdd4074bae8c32c273> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- B939a0e6583fb28fdd4074bae8c32c273 NCIT_P378 "NCI" @default.
- B939a0e6583fb28fdd4074bae8c32c273 type Axiom @default.
- B939a0e6583fb28fdd4074bae8c32c273 annotatedProperty IAO_0000115 @default.
- B939a0e6583fb28fdd4074bae8c32c273 annotatedSource NCIT_C83721 @default.
- B939a0e6583fb28fdd4074bae8c32c273 annotatedTarget "The tromethamine salt form of prodrug fosbretabulin, a water-soluble phosphate derivative of a stilbenoid phenol derived from the African bush willow (Combretum caffrum) with antineoplastic activities. Upon administration, fosbretabulin is dephosphorylated to its active metabolite, combretastatin A4, which targets and binds to tubulin dimers and prevents microtubule polymerization, thereby resulting in mitotic arrest and apoptosis in endothelial cells. As apoptotic endothelial cells detach from their substrata, tumor blood vessels collapse; the acute disruption of tumor blood flow may result in tumor necrosis." @default.