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- B93b30b5e85e311e1009a2a3a02ef5271 NCIT_P378 "NCI" @default.
- B93b30b5e85e311e1009a2a3a02ef5271 type Axiom @default.
- B93b30b5e85e311e1009a2a3a02ef5271 annotatedProperty IAO_0000115 @default.
- B93b30b5e85e311e1009a2a3a02ef5271 annotatedSource NCIT_C183521 @default.
- B93b30b5e85e311e1009a2a3a02ef5271 annotatedTarget "A boosting cancer vaccine comprised of the recombinant chimeric oncolytic vesicular stomatitis virus (VSV) viral vector VSV-GP containing as of yet undisclosed peptide(s) derived from as of yet undisclosed tumor-associated antigen(s) (TAAs) that are specific for colorectal cancer (CRC) patients, with potential immunomodulating and antineoplastic activities. Upon administration, VSV-GP-based cancer vaccine VSV-GP128 preferentially replicates in tumor cells. Due to defective antiviral host defense mechanisms in tumor cells, VSV-GP is able to replicate in tumor cells without interference. This induces VSV-mediated cytolytic activity towards the tumor cells. In addition, following the administration of the priming vaccine ATP128, the booster VSV-GP-based cancer vaccine VSV-GP128 may serve to further expand and improve the phenotyping of antigen-specific T-cells targeted to tumor cells expressing the undisclosed TAA(s), thereby further killing tumor cells expressing the TAA(s). VSV, a single-stranded RNA virus belonging to the genus Vesiculovirus of the family Rhabdoviridae, is relatively nonpathogenic to healthy humans but is able to rapidly replicate in and induce apoptosis of tumor cells. VSV-GP carries the envelope glycoprotein (GP) of the WE-HPI strain of the lymphocytic choriomeningitis virus (LCMV) instead of the native VSV glycoprotein (G). VSV-GP does not induce neutralizing antibodies to the vector itself, which may allow repeated administration. VSV-GP is also not neurotoxic, while wild-type viruses are associated with neural inflammation." @default.