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- B9424944e8b22f6c5a4bdc55b88a963ea NCIT_P378 "NCI" @default.
- B9424944e8b22f6c5a4bdc55b88a963ea type Axiom @default.
- B9424944e8b22f6c5a4bdc55b88a963ea annotatedProperty IAO_0000115 @default.
- B9424944e8b22f6c5a4bdc55b88a963ea annotatedSource NCIT_C173664 @default.
- B9424944e8b22f6c5a4bdc55b88a963ea annotatedTarget "A mimetic of the enzyme superoxide dismutase (SOD) that may potentially be used to increase the anti-cancer efficacy of stereotactic body radiation therapy (SBRT). Upon administration, rucosopasem manganese may mimic native SODs and catalyze the formation of molecular oxygen and hydrogen peroxide from the burst of superoxide anion present in the irradiated tissues upon radiation. As hydrogen peroxide is less toxic than superoxide to normal tissues, but more toxic to cancer cells, this may increase the anti-cancer efficacy of SBRT and decrease its damage to normal tissues." @default.