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- B947b2dc77d1e54d8e8bdaf75e96ab498 NCIT_P378 "NCI" @default.
- B947b2dc77d1e54d8e8bdaf75e96ab498 type Axiom @default.
- B947b2dc77d1e54d8e8bdaf75e96ab498 annotatedProperty IAO_0000115 @default.
- B947b2dc77d1e54d8e8bdaf75e96ab498 annotatedSource NCIT_C103826 @default.
- B947b2dc77d1e54d8e8bdaf75e96ab498 annotatedTarget "An orally bioavailable small molecule antagonist of the Hedgehog (Hh)-ligand cell surface receptor smoothened (Smo) with potential antineoplastic activity. Taladegib inhibits signaling that is mediated by the Hh pathway protein Smo, which may result in a suppression of the Hh signaling pathway and may lead to the inhibition of the proliferation of tumor cells in which this pathway is abnormally activated. The Hh signaling pathway plays an important role in cellular growth, differentiation and repair; constitutive activation of this pathway is associated with uncontrolled cellular proliferation and has been observed in a variety of cancers." @default.