Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/B94a63b063e41124d452f4c938125e51f> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- B94a63b063e41124d452f4c938125e51f NCIT_P378 "NCI" @default.
- B94a63b063e41124d452f4c938125e51f type Axiom @default.
- B94a63b063e41124d452f4c938125e51f annotatedProperty IAO_0000115 @default.
- B94a63b063e41124d452f4c938125e51f annotatedSource NCIT_C111906 @default.
- B94a63b063e41124d452f4c938125e51f annotatedTarget "A targeted antibody payload (TAP)-based immunoconjugate consisting of a human monoclonal antibody directed against the epidermal growth factor receptor (EGFR) conjugated, via a nonreducible thioether linker (succinimidyl trans-4-(maleimidylmethyl)cyclohexane-1-carboxylate or SMCC), to the cytotoxic agent maytansinoid mertansine (DM1), with potential antineoplastic activity. Upon intravenous administration, the monoclonal antibody moiety of laprituximab emtansine binds to and inhibits EGFR on tumor cell surfaces. Inhibition of EGFR prevents EGFR-mediated signaling and may inhibit tumor cell proliferation. After internalization, the mertansine moiety binds to tubulin and interferes with microtubule assembly/disassembly dynamics. This inhibits both cell division and the proliferation of cancer cells that express EGFR. EGFR, overexpressed by a variety of cancers, plays a key role in tumor cell proliferation and survival. Linkage of the antibody and drug, through a nonreducible linker, appears to contribute to the improved efficacy and reduced toxicity of this antibody-drug conjugate (ADC) compared to similar ADCs constructed with reducible linkers." @default.