Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/B94c016719b2f339c4878dd8d1790765a> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- B94c016719b2f339c4878dd8d1790765a NCIT_P378 "NCI" @default.
- B94c016719b2f339c4878dd8d1790765a type Axiom @default.
- B94c016719b2f339c4878dd8d1790765a annotatedProperty IAO_0000115 @default.
- B94c016719b2f339c4878dd8d1790765a annotatedSource NCIT_C71533 @default.
- B94c016719b2f339c4878dd8d1790765a annotatedTarget "An oncolytic thymidine kinase (TK)-deleted vaccinia poxvirus expressing human GM-CSF (hGM-CSF) with antineoplastic activity. Upon intratumoral or intravenous administration, pexastimogene devacirepvec selectively infects and lyses tumor cells. While vaccinia displays a natural tumor cell tropism, deletion of the TK gene increases the tumor selectivity of vaccinia by limiting viral replication to cells expressing high levels of TK, such as certain cancer cells. hGM-CSF expression by this agent helps recruit antigen presenting cells (APCs), such as dendritic cells (DCs) and macrophages, to virally infected tumor cells, thereby initiating an antitumoral immune response." @default.