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- B94dc6120ec49cef59ae1aade1ba9d7cb NCIT_P378 "NCI" @default.
- B94dc6120ec49cef59ae1aade1ba9d7cb type Axiom @default.
- B94dc6120ec49cef59ae1aade1ba9d7cb annotatedProperty IAO_0000115 @default.
- B94dc6120ec49cef59ae1aade1ba9d7cb annotatedSource NCIT_C101786 @default.
- B94dc6120ec49cef59ae1aade1ba9d7cb annotatedTarget "An orally available, small molecule inhibitor of AGC group kinases, with potential antineoplastic activity. AT13148 inhibits, in an ATP-competitive manner, the enzymatic activity of two AGC kinases, protein kinase B (PKB or AKT) and p70S6K which play key roles in the PI3K/PKB/mTOR signaling pathway. Blockade of this pathway leads to an inhibition of cell growth and the induction of apoptosis in susceptible tumor cells. PI3K/PKB/mTOR pathway is dysregulated in greater than 50% of tumors, and is often correlated with resistance and increased tumor survival. AGC group kinases are serine/threonine kinases that are regulated by secondary messengers such as cyclic AMP and lipids." @default.