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- B953bf28db4da9a0c6c287bc284041b89 NCIT_P378 "NCI" @default.
- B953bf28db4da9a0c6c287bc284041b89 type Axiom @default.
- B953bf28db4da9a0c6c287bc284041b89 annotatedProperty IAO_0000115 @default.
- B953bf28db4da9a0c6c287bc284041b89 annotatedSource NCIT_C501 @default.
- B953bf28db4da9a0c6c287bc284041b89 annotatedTarget "A pyrimidine compound and a fluorinated cytosine analog exhibiting antifungal activity. After penetration into the fungal cells, flucytosine is deaminated to its active metabolite 5-fluorouracil. 5-fluorouracil replaces uracil during fungal RNA synthesis, thereby inhibiting fungal protein synthesis. In addition, fluorouracil is further metabolized to 5-fluorodeoxyuridylic acid monophosphate, which inhibits thymidylate synthetase, thereby interrupting nucleotide metabolism, DNA synthesis and ultimately protein synthesis." @default.