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- B95b59ed26249d95d084b6b24f597f953 NCIT_P378 "NCI" @default.
- B95b59ed26249d95d084b6b24f597f953 type Axiom @default.
- B95b59ed26249d95d084b6b24f597f953 annotatedProperty IAO_0000115 @default.
- B95b59ed26249d95d084b6b24f597f953 annotatedSource NCIT_C84870 @default.
- B95b59ed26249d95d084b6b24f597f953 annotatedTarget "An orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Uprosertib binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents." @default.