Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/B95b8c10f5b86c954d7ccc94869888b38> ?p ?o ?g. }
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- B95b8c10f5b86c954d7ccc94869888b38 NCIT_P378 "NCI" @default.
- B95b8c10f5b86c954d7ccc94869888b38 type Axiom @default.
- B95b8c10f5b86c954d7ccc94869888b38 annotatedProperty IAO_0000115 @default.
- B95b8c10f5b86c954d7ccc94869888b38 annotatedSource NCIT_C226 @default.
- B95b8c10f5b86c954d7ccc94869888b38 annotatedTarget "A difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required for polyamine biosynthesis, thereby inhibiting the formation and proliferation of tumor cells. Polyamines are involved in nucleosome oligomerization and DNA conformation, creating a chromatin environment that stimulates neoplastic transformation of cells. This agent has been shown to induce apoptosis in leiomyoma cells. (NCI04)" @default.