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- B95bd83e78efd00db9dba924c97f49b35 NCIT_P378 "NCI" @default.
- B95bd83e78efd00db9dba924c97f49b35 type Axiom @default.
- B95bd83e78efd00db9dba924c97f49b35 annotatedProperty IAO_0000115 @default.
- B95bd83e78efd00db9dba924c97f49b35 annotatedSource NCIT_C62025 @default.
- B95bd83e78efd00db9dba924c97f49b35 annotatedTarget "A monoamine compound with positive inotropic activity. Dopamine is a naturally occurring catecholamine formed by decarboxylation of dehydroxyphenylalanine and a precursor of norepinephrine and epinephrine. Dopamine binds to alpha-1 and beta-1 adrenergic receptors. Mediated through myocardial beta-1 adrenergic receptors, dopamine increase heart rate and force, thereby increasing cardiac output. Alpha-1 adrenergic receptor stimulation on vascular smooth muscle, leads to vasoconstriction and results in an increase in systemic vascular resistance. Stimulation of dopaminergic receptors in renal vasculature, leads to renal blood vessel dilation, and an increase in glomerular filtration rate, renal blood flow, sodium excretion, and urine output." @default.