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- B9632c290c4f0e89e03b9a35c747a0987 NCIT_P378 "NCI" @default.
- B9632c290c4f0e89e03b9a35c747a0987 type Axiom @default.
- B9632c290c4f0e89e03b9a35c747a0987 annotatedProperty IAO_0000115 @default.
- B9632c290c4f0e89e03b9a35c747a0987 annotatedSource NCIT_C61313 @default.
- B9632c290c4f0e89e03b9a35c747a0987 annotatedTarget "A fully human monoclonal antibody directed against the receptor activator of nuclear factor kappa beta ligand (RANKL) with antiosteoclast activity. Denosumab specifically binds to RANKL and blocks the interaction of RANKL with RANK, a receptor located on osteoclast cell surfaces, resulting in inhibition of osteoclast activity, a decrease in bone resorption, and a potential increase in bone mineral density. RANKL, a protein expressed by osteoblastic cells, plays an important role in osteoclastic differentiation and activation." @default.