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- B964ce9feaff8233ff2734d70b6a9dbb0 NCIT_P378 "NCI" @default.
- B964ce9feaff8233ff2734d70b6a9dbb0 type Axiom @default.
- B964ce9feaff8233ff2734d70b6a9dbb0 annotatedProperty IAO_0000115 @default.
- B964ce9feaff8233ff2734d70b6a9dbb0 annotatedSource NCIT_C76969 @default.
- B964ce9feaff8233ff2734d70b6a9dbb0 annotatedTarget "The dihydrochloride salt form of atiprimod, an orally bioavailable small molecule belonging to the azaspirane class of cationic amphiphilic agents with anti-inflammatory, antineoplastic, and anti-angiogenic activities. Atiprimod inhibits the phosphorylation of signal transducer and activator of transcription 3 (STAT3) and AKT, blocking the signaling pathways of interleukin-6, vascular endothelial growth factor (VEGF) and downregulating the anti-apoptotic proteins Bcl-2, Bcl-XL, and Mcl-1. This results in the inhibition of cell proliferation, induction of cell cycle arrest, and apoptosis." @default.