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- B973880128c10e61b46b524f0c4340e7b NCIT_P378 "NCI" @default.
- B973880128c10e61b46b524f0c4340e7b type Axiom @default.
- B973880128c10e61b46b524f0c4340e7b annotatedProperty IAO_0000115 @default.
- B973880128c10e61b46b524f0c4340e7b annotatedSource NCIT_C175659 @default.
- B973880128c10e61b46b524f0c4340e7b annotatedTarget "A preparation of autologous T-lymphocytes that have been genetically engineered to express a T-cell receptor (TCR) specific for the tumor-associated antigen (TAA) human mesothelin (TMSLN), with potential immunomodulating and antineoplastic activities. Upon administration, the autologous anti-mesothelin TCR-expressing T-cells FH-TCR TMSLN specifically target and bind to mesothelin-expressing tumor cells. This leads to T-cell activation and T-cell mediated lysis of mesothelin-expressing tumor cells. Mesothelin, a cell surface glycoprotein involved in cell adhesion, is overexpressed in a variety of cancer cell types." @default.