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- B97d5ae641966978b2d999154ecc32dbc NCIT_P378 "NCI" @default.
- B97d5ae641966978b2d999154ecc32dbc type Axiom @default.
- B97d5ae641966978b2d999154ecc32dbc annotatedProperty IAO_0000115 @default.
- B97d5ae641966978b2d999154ecc32dbc annotatedSource NCIT_C102784 @default.
- B97d5ae641966978b2d999154ecc32dbc annotatedTarget "A humanized IgG1 monoclonal antibody against CD123 (Interleukin-3 receptor alpha chain or IL3RA) with potential antineoplastic activity. Upon intravenous administration, talacotuzumab binds to and neutralizes CD123. This may inhibit IL-3-dependent signaling and may inhibit proliferation and differentiation in CD123-positive tumor cells. CSL362 contains an engineered Fc region which increases its binding affinity to Fc-gamma receptors on the surface of natural killer (NK) cells thereby initiating antibody-dependent cellular cytotoxicity (ADCC). CD123 is normally expressed on committed blood progenitor cells in the bone marrow; its overexpression is associated with increased leukemic cell proliferation and aggressiveness." @default.