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- B97d9b30b61516e19cad4e05961bfd7c3 NCIT_P378 "NCI" @default.
- B97d9b30b61516e19cad4e05961bfd7c3 type Axiom @default.
- B97d9b30b61516e19cad4e05961bfd7c3 annotatedProperty IAO_0000115 @default.
- B97d9b30b61516e19cad4e05961bfd7c3 annotatedSource NCIT_C28837 @default.
- B97d9b30b61516e19cad4e05961bfd7c3 annotatedTarget "The calcium salt of atorvastatin, a synthetic lipid-lowering agent. Atorvastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent increases the number of LDL receptors on hepatic cell surfaces, enhancing the uptake and catabolism of LDL and reducing LDL production and the number of LDL particles, and lowers plasma cholesterol and lipoprotein levels. Like other statins, atorvastatin may also display direct antineoplastic activity, possibly by inhibiting farnesylation and geranylgeranylation of proteins such as small GTP-binding proteins, which may result in the arrest of cells in the G1 phase of the cell cycle. This agent may also sensitize tumor cells to cyctostatic drugs, possibly through the mTOR-dependent inhibition of Akt phosphorylation." @default.