Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/B9848c22ed6db8b278babce17650f26f7> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- B9848c22ed6db8b278babce17650f26f7 NCIT_P378 "KEGG" @default.
- B9848c22ed6db8b278babce17650f26f7 type Axiom @default.
- B9848c22ed6db8b278babce17650f26f7 annotatedProperty NCIT_P325 @default.
- B9848c22ed6db8b278babce17650f26f7 annotatedSource NCIT_C91447 @default.
- B9848c22ed6db8b278babce17650f26f7 annotatedTarget "Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar." @default.