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- B9879827c26c3c48fde1b9b5801b95b8c NCIT_P378 "BIOCARTA" @default.
- B9879827c26c3c48fde1b9b5801b95b8c type Axiom @default.
- B9879827c26c3c48fde1b9b5801b95b8c annotatedProperty NCIT_P325 @default.
- B9879827c26c3c48fde1b9b5801b95b8c annotatedSource NCIT_C39259 @default.
- B9879827c26c3c48fde1b9b5801b95b8c annotatedTarget "Nerve growth factor (NGF) is a neurotrophic factor that stimulates neuronal survival and growth through TrkA, a member of the trk family of tyrosine kinase receptors that also includes TrkB and TrkC. Some NGF responses are also mediated or modified by p75LNTR, a low affinity neurotrophin receptor. Binding of NGF to TrkA stimulates neuronal survival, and also proliferation. Pathways coupled to these responses are linked to TrkA through association of signaling factors with specific amino acids in the TrkA cytoplasmic domain. Cell survival through inhibition of apoptosis is signaled through activation of PI3-kinase and AKT. Ras-mediated signaling and phospholipase C both activate the MAP kinase pathway to stimulate proliferation. (This definition may be outdated - see the DesignNote.)" @default.