Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/B990ff26a4600f933c38beaf942d2cdd3> ?p ?o ?g. }
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- B990ff26a4600f933c38beaf942d2cdd3 NCIT_P378 "KEGG" @default.
- B990ff26a4600f933c38beaf942d2cdd3 type Axiom @default.
- B990ff26a4600f933c38beaf942d2cdd3 annotatedProperty NCIT_P325 @default.
- B990ff26a4600f933c38beaf942d2cdd3 annotatedSource NCIT_C91494 @default.
- B990ff26a4600f933c38beaf942d2cdd3 annotatedTarget "One of the major tasks of the renal proximal tubule (PT) is to secrete acid into the tubule lumen, thereby reabsorbing approximately 80% of the filtered bicarbonate (HCO3(-)), as well as generating "new HCO3(-)" for regulating blood pH. In the tubular lumen, filtered HCO3(-) combines with H(+) in a reaction catalyzed by CA IV. The CO2 thus produced rapidly diffuses into the tubular cells and is combined with water to produce intracellular H(+) and HCO3(-), catalyzed by soluble cytoplasmic CA II. HCO3(-) is then cotransported with Na(+) into blood via the NBC-1. The intracellular H(+) produced by CA II is secreted into the tubular lumen predominantly via the NHE-3. The PT creates the "new HCO3(-)" by taking glutamine and metabolizing it to two molecules each of NH4(+) and HCO3(-). The NH4(+) is excreted into the tubular lumen, and the HCO3(-), which is "new HCO3(-)," is returned to the blood, where it replaces the HCO3(-) lost earlier in the titration of nonvolatile acids." @default.