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- B99eac8eabad25dfbae43c86c5a62fe06 NCIT_P378 "NCI" @default.
- B99eac8eabad25dfbae43c86c5a62fe06 type Axiom @default.
- B99eac8eabad25dfbae43c86c5a62fe06 annotatedProperty IAO_0000115 @default.
- B99eac8eabad25dfbae43c86c5a62fe06 annotatedSource NCIT_C1845 @default.
- B99eac8eabad25dfbae43c86c5a62fe06 annotatedTarget "A covalent conjugate of recombinant interferon alpha, subtype 2b, and polyethylene glycol (PEG), used as an antiviral and antineoplastic agent. The biological activity of this agent is derived from its interferon alpha-2b protein moiety. Interferons alfa bind to specific cell-surface receptors, leading to the transcription and translation of genes whose protein products mediate antiviral, antiproliferative, anticancer, and immune-modulating effects. The PEG moiety lowers the clearance of interferon alpha-2b, thereby extending the duration of its therapeutic effects, but may also reduce the interferon-mediated stimulation of an immune response. (NCI04)" @default.