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- B9b2869e7415043e4639a71b03e175d47 NCIT_P378 "NCI" @default.
- B9b2869e7415043e4639a71b03e175d47 type Axiom @default.
- B9b2869e7415043e4639a71b03e175d47 annotatedProperty IAO_0000115 @default.
- B9b2869e7415043e4639a71b03e175d47 annotatedSource NCIT_C2736 @default.
- B9b2869e7415043e4639a71b03e175d47 annotatedTarget "A water-soluble phosphate prodrug of N-acetylcolchinol with potential antiangiogenesis and antineoplastic activities. ZD-6126 is converted in vivo into N-acetylcolchinol. N-acetylcolchinol binds to and destabilizes the tubulin cytoskeleton of endothelial cells in tumor blood vessels, which may result in tumor endothelial cell apoptosis, the selective occlusion of tumor blood vessels, cessation of tumor blood flow, and tumor necrosis." @default.