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- B9b3b8dd47759e0a9dcc8c2babfc91493 NCIT_P378 "NCI" @default.
- B9b3b8dd47759e0a9dcc8c2babfc91493 type Axiom @default.
- B9b3b8dd47759e0a9dcc8c2babfc91493 annotatedProperty IAO_0000115 @default.
- B9b3b8dd47759e0a9dcc8c2babfc91493 annotatedSource NCIT_C64782 @default.
- B9b3b8dd47759e0a9dcc8c2babfc91493 annotatedTarget "The hydrochloride salt form of verubulin, a quinazoline derivative with potential dual antineoplastic activities. Verubulin binds to and inhibits tubulin polymerization and interrupts microtubule formation, resulting in disruption of mitotic spindle assembly, cell cycle arrest in the G2/M phase, and cell death. This agent is not a substrate for several subtypes of multidrug resistance ABC transporters, such as P-glycoprotein, multidrug resistance-associated protein 1 (MRP1), and breast cancer resistance protein 1 (BCRP1); therefore, it may be useful for treating multidrug resistant (MDR) tumors that express these transporters. In addition, as a vascular disrupting agent (VDA), verubulin appears to disrupt tumor microvasculature specifically, which may result in acute ischemia and massive tumor cell death." @default.