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- B9b8d72cc8fc7cbccb7aa4954d9054bc1 NCIT_P378 "NCI" @default.
- B9b8d72cc8fc7cbccb7aa4954d9054bc1 type Axiom @default.
- B9b8d72cc8fc7cbccb7aa4954d9054bc1 annotatedProperty IAO_0000115 @default.
- B9b8d72cc8fc7cbccb7aa4954d9054bc1 annotatedSource NCIT_C1083 @default.
- B9b8d72cc8fc7cbccb7aa4954d9054bc1 annotatedTarget "A bacterial enterotoxin with potential immunostimulatory activity. Staphylococcal enterotoxin A (SEA), a gram positive bacterial superantigen (SAg), is a potent stimulator of T-cell activation. SEA superantigen binds directly to class II major histocompatibility complex (MHC) molecules and to the V beta region of the T-cell receptor (TCR), leading to an amplified T-cell response. In response to SEA, both CD4+ and CD8+ cells proliferate, secrete cytokines, and demonstrate enhanced cytotoxic activity against a broad range of antigens. Vaccination with the SEA protein, administered by direct transfection into tumor cells, may elicit a non-specific cytotoxic T-cell (CTL) response and result in decreased tumor cell growth." @default.